Cisco’s documentation implies that to enable jumbo frames on the 5K and 9K line, one must simply set mtu 9216 on the physical and logical L1/L2 interfaces:

Configure and Verify Maximum Transmission Unit on Cisco Nexus Platforms

However, currently working with the 93180YC-EX and previously worked with the 5672UP, I can tell you that both are actually based on the obscureĀ 6K line.

So, in order to get jumbo frames, you have to do this additional step:

policy-map type network-qos jumbo
  class type network-qos class-default
          mtu 9216
system qos
  service-policy type network-qos jumbo

After applying this, also do a set mtu 9216 on the on the L3 SVIs:

Switch(config)#interface Vlan200
  no shutdown
  mtu 9216

Switch# show interface vl200
Vlan200 is up, line protocol is up, autostate enabled
Hardware is EtherSVI, address is 70ea.1a44.d0a7
Internet Address is
MTU 9216 bytes, BW 1000000 Kbit, DLY 10 usec,

93180YC – Jumbo Frames